The Simultaneous Formation of Acrylamide, ß-carbolines, and Advanced Glycation End Products in a Chemical Model System: Effect of Multiple Precursor Amino Acids.
Front Nutr
; 9: 852717, 2022.
Article
em En
| MEDLINE
| ID: mdl-35356734
This study investigated the effect of multiple precursor amino acids on the simultaneous formation of acrylamide, ß-carbolines (i. e., harmane and norharmane), and advanced glycation end products (AGEs) [i.e., Nε-(carboxymethyl)lysine and Nε-(carboxyethyl)lysine] via a chemical model system. This model system was established with single or multiple precursor amino acids, including lysine-glucose (Lys/Glu), asparagine-glucose (Asn/Glu), tryptophan-glucose (Trp/Glu), and a combination of these amino acids (Com/Glu). Kinetic parameters were calculated by multiresponse non-linear regression models. We found that the k values of the AGEs and of acrylamide decreased, while those of harmane increased in the Com/Glu model when heated to 170 and 200°C. Our results indicated that the precursor amino acid of acrylamide and AGEs compete for α-dicarbonyl compounds, leading to a decrease in the formation of AGEs and acrylamide. Moreover, compared with asparagine, the precursor amino acid of ß-carbolines was more likely to react with acetaldehyde by Pictet-Spengler condensation, which increased the formation of harmane and decreased the formation of acrylamide via the acrolein pathway.
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MEDLINE
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En
Ano de publicação:
2022
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Article