CD38 deficiency protects the retina from ischaemia/reperfusion injury partly via suppression of TLR4/MyD88/NF-&#954;B signalling.

Chen, Guiping; Yan, Feng; Wei, Wei; Wang, Feifei; Wang, Zhiruo; Nie, Jiahe; Jin, Ming; Pang, Yulian; Qin, Mengqi; Wang, Lingfang; Zhang, Xu

CD38 deficiency protects the retina from ischaemia/reperfusion injury partly via suppression of TLR4/MyD88/NF-κB signalling.

Chen, Guiping; Yan, Feng; Wei, Wei; Wang, Feifei; Wang, Zhiruo; Nie, Jiahe; Jin, Ming; Pang, Yulian; Qin, Mengqi; Wang, Lingfang; Zhang, Xu.

Afiliação

Chen G; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Yan F; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China; School of Pharmacy, Nanchang University, Nanchang, Jiangxi, China.
Wei W; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Wang F; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Wang Z; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Nie J; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Jin M; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Pang Y; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Qin M; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China.
Wang L; Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
Zhang X; Affiliated Eye Hospital of Nanchang University, Jiangxi Clinical Research Center of Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Nanchang, Jiangxi, China. Electronic address: xuzhang19@163.com.

Exp Eye Res ; 219: 109058, 2022 06.

Article em En | MEDLINE | ID: mdl-35364100

Assuntos

Traumatismo por Reperfusão; Receptor 4 Toll-Like; Animais; Citocinas/metabolismo; Interleucina-6/metabolismo; Isquemia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Fator 88 de Diferenciação Mieloide/genética; NF-kappa B/metabolismo; Traumatismo por Reperfusão/metabolismo; Traumatismo por Reperfusão/prevenção & controle; Retina/metabolismo; Sirtuína 1/metabolismo; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

CD38; Ischaemia-reperfusion; Microglia; Pro-inflammatory cytokines; Retina; TLR4/MyD88/NF-κB

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Receptor 4 Toll-Like Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Receptor 4 Toll-Like Idioma: En Ano de publicação: 2022 Tipo de documento: Article