Promyelocytic leukemia protein is a restriction factor for Junín virus independently of Z matrix protein.
Biochem Biophys Res Commun
; 606: 168-173, 2022 05 28.
Article
em En
| MEDLINE
| ID: mdl-35364325
ABSTRACT
The New World (NW) mammarenavirus Junín (JUNV) is the etiological agent of Argentine hemorrhagic fever, a human endemic disease of Argentina. Promyelocytic leukemia protein (PML) has been reported as a restriction factor for several viruses although the mechanism/s behind PML-mediated antiviral effect may be diverse and are a matter of debate. Previous studies have reported a nuclear to cytoplasm translocation of PML during the murine Old World mammarenavirus lymphocytic choriomeningitis virus (LCMV) infection. This translocation was found to be mediated by the viral Z protein. Here, we show that PML restricts JUNV infection in human A549 cells. However, in contrast to LCVM, JUNV infection enhances PML expression and PML is not translocated to the cytoplasm neither it colocalizes with JUNV Z protein. Our study demonstrates that a NW mammarenavirus as JUNV interacts differently with the antiviral protein PML than LCMV.
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Base de dados:
MEDLINE
Assunto principal:
Vírus Junin
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Proteína da Leucemia Promielocítica
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Febre Hemorrágica Americana
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article