Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation.
Hum Immunol
; 83(6): 494-498, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35365357
ABSTRACT
The post-transplant development of donor-specific antibodies (DSAs) initiates the antibody-mediated rejection, which is associated with an increased rate of graft loss. Therefore, risk prediction of de novo DSA (dnDSA) is important for understanding long-term prognostic implications for kidney transplantation outcomes. Cytotoxic T lymphocyte antigen-4 (CTLA-4), a cell surface molecule, suppresses T cell responses. Single-nucleotide polymorphisms (SNPs) in CTLA-4 are known to be associated with acute rejection; however, their association with dnDSA formation is not established. In the present study, we investigated the impact of CTLA-4 SNPs on dnDSA formation after kidney transplantation (KT) by analyzing three CTLA-4 SNPs (rs231775, rs3087243, and rs5742909) in 88 recipients. Patients with the GG genotype of CTLA-4 SNPs rs231775 and rs3087243 had higher rates of dnDSA formation than patients with the AA genotype or heterozygous genotypes. In conclusion, our findings indicate that CTLA-4 SNPs are predisposing factors for dnDSA formation after KT.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
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Antígeno CTLA-4
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Isoanticorpos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article