Bioactive neolignans and lignans from the roots of Paeonia lactiflora.
Chin J Nat Med
; 20(3): 210-214, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35369965
ABSTRACT
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 µmol·-1.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Paeonia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article