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Bioactive neolignans and lignans from the roots of Paeonia lactiflora.
Xia, Huan; Zhang, Jing-Fang; Wang, Ling-Yan; Xia, Gui-Yang; Wang, Ya-Nan; Wu, Yu-Zhuo; Lin, Peng-Cheng; Xiong, Liang; Lin, Sheng.
Afiliação
  • Xia H; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Zhang JF; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Wang LY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Xia GY; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Wang YN; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
  • Wu YZ; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Lin PC; College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China. Electronic address: qhlpc@126.com.
  • Xiong L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: xiling@cdutcm.edu.cn.
  • Lin S; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. Electronic address: lsznn@126.com.
Chin J Nat Med ; 20(3): 210-214, 2022 Mar.
Article em En | MEDLINE | ID: mdl-35369965
ABSTRACT
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 µmol·-1.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lignanas / Paeonia Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lignanas / Paeonia Idioma: En Ano de publicação: 2022 Tipo de documento: Article