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Butyrophilins: γδ T Cell Receptor Ligands, Immunomodulators and More.
Herrmann, Thomas; Karunakaran, Mohindar M.
Afiliação
  • Herrmann T; Institute for Virology and Immunobiology, Julius Maximilians Universität Würzburg, Würzburg, Germany.
  • Karunakaran MM; Institute for Virology and Immunobiology, Julius Maximilians Universität Würzburg, Würzburg, Germany.
Front Immunol ; 13: 876493, 2022.
Article em En | MEDLINE | ID: mdl-35371078
ABSTRACT
Butyrophilins (BTN) are relatives of the B7 family (e.g., CD80, PD-L1). They fulfill a wide range of functions including immunomodulation and bind to various receptors such as the γδ T cell receptor (γδTCR) and small molecules. One intensively studied molecule is BTN3A1, which binds via its cytoplasmic B30.2 domain, metabolites of isoprenoid synthesis, designated as phosphoantigen (PAg), The enrichment of PAgs in tumors or infected cells is sensed by Vγ9Vδ2 T cells, leading to the proliferation and execution of effector functions to remove these cells. This article discusses the contribution of BTNs, the related BTNL molecules and SKINT1 to the development, activation, and homeostasis of γδ T cells and their immunomodulatory potential, which makes them interesting targets for therapeutic intervention.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Receptores de Antígenos de Linfócitos T gama-delta Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Receptores de Antígenos de Linfócitos T gama-delta Idioma: En Ano de publicação: 2022 Tipo de documento: Article