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A Robust Method for Perfusable Microvascular Network Formation In Vitro.
Wan, Zhengpeng; Zhong, Amy X; Zhang, Shun; Pavlou, Georgios; Coughlin, Mark F; Shelton, Sarah E; Nguyen, Huu Tuan; Lorch, Jochen H; Barbie, David A; Kamm, Roger D.
Afiliação
  • Wan Z; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Zhong AX; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Zhang S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Pavlou G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Coughlin MF; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Shelton SE; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Nguyen HT; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Lorch JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Barbie DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Kamm RD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Small Methods ; 6(6): e2200143, 2022 06.
Article em En | MEDLINE | ID: mdl-35373502
ABSTRACT
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neovascularização Fisiológica / Microvasos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neovascularização Fisiológica / Microvasos Idioma: En Ano de publicação: 2022 Tipo de documento: Article