General orientation transform for the estimation of fiber orientations in white matter tissues.
Magn Reson Med
; 88(2): 945-961, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35381107
ABSTRACT
PURPOSE:
The orientation distribution function (ODF), which is obtained from the radial integral of the probability density function weighted by rn$$ {r}^n $$ ( r$$ r $$ is the radial length), has been used to estimate fiber orientations of white matter tissues. Currently, there is no general expression of the ODF that is suitable for any n value in the HARDI methods. THEORY ANDMETHODS:
A novel methodology is proposed to calculate the ODF for any n>-1$$ n>-1 $$ through the Taylor series expansion and a generalized expression for -1RESULTS:
coGOT can resolve crossing fibers with higher resolution, performs better robustness, generates fewer spurious lobes in glyphs, and thus provides distinct improvement in the tractography. The evaluations show coGOT's superior capability in reconstructing the fiber orientations from dMRI signals.CONCLUSIONS:
Generalization of the ODF allows us to obtain a wide range of HARDI estimators to select suitable candidates for composite formulation. The optimized estimator coGOT has great potential for studying neural architecture and serving as fiber tracking tools.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Substância Branca
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article