Multi-omic rejuvenation of human cells by maturation phase transient reprogramming.

Gill, Diljeet; Parry, Aled; Santos, Fátima; Okkenhaug, Hanneke; Todd, Christopher D; Hernando-Herraez, Irene; Stubbs, Thomas M; Milagre, Inês; Reik, Wolf

Gill, Diljeet; Parry, Aled; Santos, Fátima; Okkenhaug, Hanneke; Todd, Christopher D; Hernando-Herraez, Irene; Stubbs, Thomas M; Milagre, Inês; Reik, Wolf.

Afiliação

Gill D; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
Parry A; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
Santos F; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
Okkenhaug H; Imaging Facility, Babraham Institute, Cambridge, United Kingdom.
Todd CD; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
Hernando-Herraez I; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.
Stubbs TM; Chronomics Limited, London, United Kingdom.
Milagre I; Laboratory for Epigenetic Mechanisms/Chromosome Dynamics Lab, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Reik W; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom.

Elife ; 112022 04 08.

Article em En | MEDLINE | ID: mdl-35390271

Assuntos

Células-Tronco Pluripotentes Induzidas; Rejuvenescimento; Reprogramação Celular/genética; Metilação de DNA; Epigenoma; Epigenômica/métodos; Fibroblastos; Humanos; Pessoa de Meia-Idade

Palavras-chave

DNA methylation; ageing; genetics; genomics; human; regenerative medicine; rejuvenation; reprogramming; stem cells; transcription

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rejuvenescimento / Células-Tronco Pluripotentes Induzidas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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