Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer.
Cell
; 185(8): 1356-1372.e26, 2022 04 14.
Article
em En
| MEDLINE
| ID: mdl-35395179
ABSTRACT
Tumor-resident intracellular microbiota is an emerging tumor component that has been documented for a variety of cancer types with unclear biological functions. Here, we explored the functional significance of these intratumor bacteria, primarily using a murine spontaneous breast-tumor model MMTV-PyMT. We found that depletion of intratumor bacteria significantly reduced lung metastasis without affecting primary tumor growth. During metastatic colonization, intratumor bacteria carried by circulating tumor cells promoted host-cell survival by enhancing resistance to fluid shear stress by reorganizing actin cytoskeleton. We further showed that intratumor administration of selected bacteria strains isolated from tumor-resident microbiota promoted metastasis in two murine tumor models with significantly different levels of metastasis potential. Our findings suggest that tumor-resident microbiota, albeit at low biomass, play an important role in promoting cancer metastasis, intervention of which might therefore be worth exploring for advancing oncology care.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Microbiota
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Metástase Neoplásica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article