Circling back to PTEN: Fumarate inhibits canonical tumor suppressor.

Claridge, Sally E; Hopkins, Benjamin D

Claridge, Sally E; Hopkins, Benjamin D.

Afiliação

Claridge SE; Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.
Hopkins BD; Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA. Electronic address: benjamin.hopkins@mssm.edu.

Mol Cell ; 82(7): 1244-1245, 2022 04 07.

Article em En | MEDLINE | ID: mdl-35395197

ABSTRACT

ABSTRACT

Ge et al. (2022) describes an inhibitory, post-translational modification of PTEN at C211 by fumarate, which offers new insight into the integration of PI3K signaling and metabolism via a potential feedforward regulatory mechanism involving a PI3K-glucose-fumarate-PTEN axis.

Assuntos

Fumaratos; Fosfatidilinositol 3-Quinases; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Fumaratos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Fumaratos Idioma: En Ano de publicação: 2022 Tipo de documento: Article