Both high glucose and phosphate overload promote senescence-associated calcification of vascular muscle cells.

Zhang, Mingming; Li, Tianyu; Tu, Zhenzhen; Zhang, Yuying; Wang, Xuerong; Zang, Dandan; Xu, Deping; Feng, Yang; He, Fan; Ni, Mingyue; Wang, Deguang; Zhou, Haisheng

Zhang, Mingming; Li, Tianyu; Tu, Zhenzhen; Zhang, Yuying; Wang, Xuerong; Zang, Dandan; Xu, Deping; Feng, Yang; He, Fan; Ni, Mingyue; Wang, Deguang; Zhou, Haisheng.

Afiliação

Zhang M; Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Li T; Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Tu Z; Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China.
Zhang Y; Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Wang X; Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China.
Zang D; Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Xu D; The Center for Scientific Research of Anhui Medical University, Hefei, China.
Feng Y; Department of Clinical Laboratory, Affiliated Hefei Hospital of Anhui Medical University, Hefei, China.
He F; Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China.
Ni M; Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China.
Wang D; Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, China.
Zhou H; Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. wangdeguang@ahmu.edu.cn.

Int Urol Nephrol ; 54(10): 2719-2731, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35396645

Assuntos

Músculo Liso Vascular; Calcificação Vascular; Animais; Células Cultivadas; Glucose/metabolismo; Glucose/farmacologia; Camundongos; Músculo Liso Vascular/metabolismo; Miócitos de Músculo Liso/metabolismo; NF-kappa B/metabolismo; Osteogênese/fisiologia; Fosfatos; Sirtuína 1/metabolismo; Calcificação Vascular/metabolismo; beta-Galactosidase/metabolismo; beta-Galactosidase/farmacologia

Palavras-chave

High glucose; High phosphate; SIRT1; Senescence; Vascular calcification

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcificação Vascular / Músculo Liso Vascular Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcificação Vascular / Músculo Liso Vascular Idioma: En Ano de publicação: 2022 Tipo de documento: Article