Effects of astrocytes and microglia on neuroinflammation after spinal cord injury and related immunomodulatory strategies.
Int Immunopharmacol
; 108: 108754, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35397392
ABSTRACT
Spinal cord injury (SCI) is a catastrophic event which is still without adequate therapies. Neuroinflammation is the main pathogenesis of secondary damage post-SCI, leading to tissue loss and neurological dysfunction. Previous studies have shown that microglia and astrocytes are the major immune cells in the central nervous system (CNS) and play a crucial role in modulating neuroinflammatory responses. In this study, we mainly review the effects of neuroinflammation in SCI, focusing on the contributions of microglia and astrocytes and their cross-talk. Furthermore, we will also discuss therapeutic strategies on how to regulate their immunophenotype to suppress robust inflammation and facilitate injury prognosis.
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Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Microglia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article