State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities.
J Clin Biochem Nutr
; 70(2): 175-181, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35400815
ABSTRACT
We have reported that refractory functional dyspepsia patients with pancreatic enzyme abnormalities (FD-P). We tried to analyze the prevalence of exocrine pancreatic insufficiency (EPI) in FD-P patients to clarify whether the pathophysiology of FD patients including clinical symptoms and quality of life were associated with EPI. We enrolled forty-nine patients presenting with typical symptoms of FD-P patients (nâ
=â
20) and asymptomatic patients with pancreatic enzyme abnormalities (AP-P) (nâ
=â
29). Five pancreatic enzymes (p-amylase, lipase, elastase-1, trypsin, and PLA2) were measured and STAI-state/-trait and SF-8 were evaluated. Pancreatic exocrine function was analyzed using N-benzoyl-l-tyrosyl-p-aminobenzoic acid (BT-PABA). There were no significant differences in patient background between FD-P and AP-P patients. BT-PABA test scores for FD-P patients (61.67â
±â
5.55) were significantly (pâ
=â
0.01) lower than in AP-P patients (95.38â
±â
2.36). Physical component scale (PCS) in FD-P patients was significantly (pâ
=â
0.002) lower than that in AP-P patients. STAI-state was relatively (pâ
=â
0.054) associated with BT-PABA test in FD-P and AP-P patients by multiple logistic regression analysis. The prevalence of EPI in FD-P patients was significantly higher than that in AP-P patients and was relatively associated with state of anxiety. Further studies will be needed to clarify how EPI or pancreatic enzyme abnormalities are associated with the pathophysiology of FD-P patients.
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MEDLINE
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En
Ano de publicação:
2022
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Article