Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype.
ChemMedChem
; 17(12): e202200161, 2022 06 20.
Article
em En
| MEDLINE
| ID: mdl-35403825
ABSTRACT
Deep annotation of a library of 4-anilinoquin(az)olines led to the identification of 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 16 as a potent inhibitor (IC50 =14â
nM) of Protein Kinase Novel 3 (PKN3) with micromolar activity in cells. Compound 16 is a potential tool compound to study the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia. These 4-anilinoquin(az)olines may also be useful tools to uncover the therapeutic potential of PKN3 inhibition in a broad range of diseases.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Inibidores de Proteínas Quinases
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article