Metformin Treatment Regulates the Expression of Molecules Involved in Adiponectin and Insulin Signaling Pathways in Endometria from Women with Obesity-Associated Insulin Resistance and PCOS.

Oróstica, Maria Lorena; Astorga, Isis; Plaza-Parrochia, Francisca; Poblete, Cristian; Carvajal, Rodrigo; García, Víctor; Romero, Carmen; Vega, Margarita

Oróstica, Maria Lorena; Astorga, Isis; Plaza-Parrochia, Francisca; Poblete, Cristian; Carvajal, Rodrigo; García, Víctor; Romero, Carmen; Vega, Margarita.

Afiliação

Oróstica ML; Laboratorio de Fisiopatología Celular y Cáncer (FICEC), Centro de Investigación Biomédica (CIB), Facultad de Medicina, Universidad Diego Portales, Santiago 8370007, Chile.
Astorga I; Laboratorio de Comunicaciones Celulares, Programa de Biología Celular y Molecular, Centro de Estudios en Ejercicio, Metabolismo y Cáncer (CEMC), Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Plaza-Parrochia F; Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santos Dumont #999, Santiago 8380456, Chile.
Poblete C; Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santos Dumont #999, Santiago 8380456, Chile.
Carvajal R; Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santos Dumont #999, Santiago 8380456, Chile.
García V; Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santos Dumont #999, Santiago 8380456, Chile.
Romero C; Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santos Dumont #999, Santiago 8380456, Chile.
Vega M; Laboratory of Endocrinology and Reproductive Biology, Clinical Hospital, University of Chile, Santos Dumont #999, Santiago 8380456, Chile.

Int J Mol Sci ; 23(7)2022 Apr 01.

Article em En | MEDLINE | ID: mdl-35409282

Assuntos

Resistência à Insulina; Metformina; Síndrome do Ovário Policístico; Adiponectina/metabolismo; Endométrio/metabolismo; Feminino; Humanos; Insulina/metabolismo; Metformina/metabolismo; Metformina/farmacologia; Metformina/uso terapêutico; Obesidade/complicações; Obesidade/tratamento farmacológico; Obesidade/metabolismo; Síndrome do Ovário Policístico/metabolismo; Transdução de Sinais; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

PCOS; adiponectin; endometrium; insulin resistance; metformin; obesity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Metformina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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