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Thoracic Aortic Diameter and Cardiovascular Events and Mortality among Women and Men.
Rueda-Ochoa, Oscar L; Bons, Lidia R; Zhu, Fang; Rohde, Sofie; El Ghoul, Khalid; Budde, Ricardo P J; Ikram, M Kamran; Deckers, Jaap W; Vernooij, Meike W; Franco, Oscar H; van der Lugt, Aad; Bos, Daniel; Roos-Hesselink, Jolien W; Kavousi, Maryam.
Afiliação
  • Rueda-Ochoa OL; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Bons LR; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Zhu F; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Rohde S; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • El Ghoul K; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Budde RPJ; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Ikram MK; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Deckers JW; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Vernooij MW; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Franco OH; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • van der Lugt A; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Bos D; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Roos-Hesselink JW; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
  • Kavousi M; From the Departments of Epidemiology (O.L.R.O., F.Z., M.K.I., M.W.V., O.H.F., D.B., M.K.), Cardiology (L.R.B., S.R., K.E.G., J.W.D., J.W.R.H.), Radiology and Nuclear Medicine (R.P.J.B., M.W.V., A.v.d.L., D.B.), and Neurology (M.K.I.), Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 300
Radiology ; 304(1): 208-215, 2022 07.
Article em En | MEDLINE | ID: mdl-35412363
ABSTRACT
Background Thoracic aortic diameter may have a role as a biomarker for major adverse cardiovascular events. Purpose To evaluate the sex-specific association of the diameters of the ascending (AA) and descending (DA) thoracic aorta with risk of stroke, coronary heart disease, heart failure, cardiovascular mortality, and all-cause mortality. Materials and Methods Study participants from the population-based Rotterdam Study who underwent multidetector-row CT between 2003 and 2006 were evaluated. Cox proportional hazard models were conducted to evaluate the associations of AA and DA diameters indexed and not indexed for body mass index (BMI) with cardiovascular events and mortality for men and women. Hazard ratios (HRs) were calculated per 1-unit greater SD of aortic diameters. Results A total of 2178 participants (mean age, 69 years; 55% women) were included. Mean follow-up was 9 years. Each 0.23-mm/(kg/m2) larger BMI-indexed AA diameter was associated with a 33% higher cardiovascular mortality risk in women (HR, 1.33; 95% CI 1.03, 1.73). Each 0.16-mm/(kg/m2) larger BMI-indexed DA diameter was associated with a 38% higher risk of stroke (HR, 1.38; 95% CI 1.07, 1.78) and with a 46% greater risk of cardiovascular mortality (HR, 1.46; 95% CI 1.10, 1.94) in women. Larger BMI-indexed AA and DA diameters were associated with greater risk of all-cause mortality in both sexes. Conclusion Larger ascending and descending thoracic aortic diameters indexed by body mass index were associated with greater risk of adverse cardiovascular outcomes and mortality in women and men. Clinical trial registration no. NTR6831 © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Williams in this issue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Acidente Vascular Cerebral Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Acidente Vascular Cerebral Idioma: En Ano de publicação: 2022 Tipo de documento: Article