Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.
Trends Mol Med
; 28(6): 443-451, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35414478
ABSTRACT
Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic therapies are based on ion channel-blocking drugs that further downregulate these channels and exhibit proarrhythmic risk. Recent studies have shown that inhibition of the protein kinase RNA-like ER kinase (PERK) arm of the unfolded protein response (UPR) prevents select cardiac ion channel downregulation and plays a protective role against arrhythmias. Prevention of ion channel downregulation represents as a novel therapeutic strategy to treat arrhythmias in myocardial infarction and heart failure.
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1
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article