A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines.
Commun Biol
; 5(1): 352, 2022 04 13.
Article
em En
| MEDLINE
| ID: mdl-35418660
ABSTRACT
Structural synaptic plasticity may underlie experience and learning-dependent changes in cortical circuits. In contrast to excitatory pyramidal neurons, insight into the structural plasticity of inhibitory neurons remains limited. Interneurons are divided into various subclasses, each with specialized functions in cortical circuits. Further knowledge of subclass-specific structural plasticity of interneurons is crucial to gaining a complete mechanistic understanding of their contribution to cortical plasticity overall. Here, we describe a subpopulation of superficial cortical multipolar interneurons expressing vasoactive intestinal peptide (VIP) with high spine densities on their dendrites located in layer (L) 1, and with the electrophysiological characteristics of bursting cells. Using longitudinal imaging in vivo, we found that the majority of the spines are highly dynamic, displaying lifetimes considerably shorter than that of spines on pyramidal neurons. Using correlative light and electron microscopy, we confirmed that these VIP spines are sites of excitatory synaptic contacts, and are morphologically distinct from other spines in L1.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Intestinal Vasoativo
/
Interneurônios
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article