A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops).
Mol Cell Oncol
; 8(6): 2007028, 2021.
Article
em En
| MEDLINE
| ID: mdl-35419470
ABSTRACT
How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulation, by impairing the recruitment of RNAseH1 to the regulatory regions of mtDNA.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2021
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Article