Your browser doesn't support javascript.
loading
Optimizing the montage for cerebellar transcranial alternating current stimulation (tACS): a combined computational and experimental study.
Sadeghihassanabadi, Fatemeh; Misselhorn, Jonas; Gerloff, Christian; Zittel, Simone.
Afiliação
  • Sadeghihassanabadi F; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
  • Misselhorn J; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
  • Gerloff C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
  • Zittel S; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
J Neural Eng ; 19(2)2022 05 04.
Article em En | MEDLINE | ID: mdl-35421852
Objective. The application of cerebellar transcranial alternating current stimulation (tACS) is limited by the absence of commonly agreed montages and also the presence of unpleasant side effects. We aimed to find the most effective cerebellar tACS montage with minimum side effects (skin sensations and phosphenes).Approach. We first simulated cerebellar tACS with five montages (return electrode on forehead, buccinator, jaw, and neck positions, additionally focal montage with high-definition ring electrodes) to compare induced cerebellar current, then stimulated healthy participants and evaluated side effects for different montages and varying stimulation frequencies.Main results. The simulation revealed a descending order of current density in the cerebellum from forehead to buccinator, jaw, neck and ring montage respectively. Montages inducing higher current intensity in the eyeballs during the simulation resulted in stronger and broader phosphenes during tACS sessions. Strong co-stimulation of the brainstem was observed for the neck. Skin sensations did not differ between montages or frequencies. We propose the jaw montage as an optimal choice for maximizing cerebellar stimulation while minimizing unwanted side effects.Significance. These findings contribute to adopting a standard cerebellar tACS protocol. The combination of computational modelling and experimental data offers improved experimental control, safety, effectiveness, and reproducibility to all brain stimulation practices.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estimulação Transcraniana por Corrente Contínua Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estimulação Transcraniana por Corrente Contínua Idioma: En Ano de publicação: 2022 Tipo de documento: Article