MiR-149-5p promotes ß-catenin-induced goat hair follicle stem cell differentiation.
In Vitro Cell Dev Biol Anim
; 58(4): 325-334, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35426064
ABSTRACT
The Yangtze River Delta white goat is a unique goat species that can produce superior-quality brush hair. The formation of superior-quality brush hair cannot occur without goat hair follicle stem cell differentiation. However, knowledge regarding the regulatory role of miR-149-5p in hair follicle stem cell differentiation is limited. Here, we found that miR-149-5p is widely expressed in the tissues of Yangtze River Delta white goats, but its expression in the skin tissue of superior-quality brush hair goats is high compared to normal- quality goats. The functional studies showed that miR-149-5p overexpression markedly facilitated hair follicle stem cell differentiation, whereas inhibiting miR-149-5p inhibited hair follicle stem cell differentiation. These results more clearly elucidate the regulatory role of miR-149-5p in hair follicle stem cell growth.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Folículo Piloso
/
MicroRNAs
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article