Fast Ion-Beam Inactivation of Viruses, Where Radiation Track Structure Meets RNA Structural Biology.
Radiat Res
; 198(1): 68-80, 2022 07 01.
Article
em En
| MEDLINE
| ID: mdl-35436347
ABSTRACT
Here we show an interplay between the structures present in ionization tracks and nucleocapsid RNA structural biology, using fast ion-beam inactivation of the severe acute respiratory syndrome coronavirus (SARS-CoV) virion as an example. This interplay could be a key factor in predicting dose-inactivation curves for high-energy ion-beam inactivation of virions. We also investigate the adaptation of well-established cross-section data derived from radiation interactions with water to the interactions involving the components of a virion, going beyond the density-scaling approximation developed previously. We conclude that solving one of the grand challenges of structural biology - the determination of RNA tertiary/quaternary structure - is linked to predicting ion-beam inactivation of viruses and that the two problems can be mutually informative. Indeed, our simulations show that fast ion beams have a key role to play in elucidating RNA tertiary/quaternary structure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
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Inativação de Vírus
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SARS-CoV-2
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Conformação de Ácido Nucleico
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article