Integrative analysis of therapy resistance and transcriptomic profiling data in glioblastoma cells identifies sensitization vulnerabilities for combined modality radiochemotherapy.

Schnöller, Leon Emanuel; Albrecht, Valerie; Brix, Nikko; Nieto, Alexander Edward; Fleischmann, Daniel Felix; Niyazi, Maximilian; Hess, Julia; Belka, Claus; Unger, Kristian; Lauber, Kirsten; Orth, Michael

Schnöller, Leon Emanuel; Albrecht, Valerie; Brix, Nikko; Nieto, Alexander Edward; Fleischmann, Daniel Felix; Niyazi, Maximilian; Hess, Julia; Belka, Claus; Unger, Kristian; Lauber, Kirsten; Orth, Michael.

Afiliação

Schnöller LE; Department of Radiation Oncology, University Hospital, LMU München, Marchioninistrasse 15, 81377, Munich, Germany.
Albrecht V; Department of Radiation Oncology, University Hospital, LMU München, Marchioninistrasse 15, 81377, Munich, Germany.
Brix N; Department of Radiation Oncology, University Hospital, LMU München, Marchioninistrasse 15, 81377, Munich, Germany.
Nieto AE; Department of Radiation Oncology, University Hospital, LMU München, Marchioninistrasse 15, 81377, Munich, Germany.
Fleischmann DF; Department of Radiation Oncology, University Hospital, LMU München, Marchioninistrasse 15, 81377, Munich, Germany.
Niyazi M; German Cancer Consortium (DKTK), Munich, Germany.
Hess J; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Belka C; Department of Radiation Oncology, University Hospital, LMU München, Marchioninistrasse 15, 81377, Munich, Germany.
Unger K; German Cancer Consortium (DKTK), Munich, Germany.
Lauber K; Research Unit Radiation Cytogenetics, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
Orth M; Clinical Cooperation Group 'Personalized Radiotherapy in Head and Neck Cancer' Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Neuherberg, Germany.

Radiat Oncol ; 17(1): 79, 2022 Apr 19.

Article em En | MEDLINE | ID: mdl-35440003

Assuntos

Neoplasias Encefálicas; Glioblastoma; Antineoplásicos Alquilantes/uso terapêutico; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/terapia; Linhagem Celular Tumoral; Quimiorradioterapia; Terapia Combinada; Metilases de Modificação do DNA/genética; Metilases de Modificação do DNA/metabolismo; Metilases de Modificação do DNA/uso terapêutico; Enzimas Reparadoras do DNA/genética; Enzimas Reparadoras do DNA/metabolismo; Enzimas Reparadoras do DNA/uso terapêutico; Glioblastoma/tratamento farmacológico; Glioblastoma/terapia; Humanos; RNA Mensageiro/genética; Temozolomida/farmacologia; Temozolomida/uso terapêutico; Transcriptoma

Palavras-chave

ATM; ATR; Chemosensitization; Clonogenic survival; Correlation analysis; DNA damage response; Glioblastoma; LIG4; Radiosensitization; Radiotherapy; Temozolomide; Therapy resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article