Baseline soluble MICA levels act as a predictive biomarker for the efficacy of regorafenib treatment in colorectal cancer.
BMC Cancer
; 22(1): 428, 2022 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-35443621
ABSTRACT
BACKGROUND:
To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined whether its plasma levels were associated with regorafenib activity in terms of progression-free survival (PFS) in patients with CRC.METHODS:
Human CRC cell line HCT116 and HT29 cells were treated with regorafenib and its pharmacologically active metabolites, M2 or M5 at the same concentrations as those in sera of patients. We also examined the sMICA levels and the area under the plasma concentration-time curve of regorafenib, M2 and M5.RESULTS:
Regorafenib, M2, and M5 significantly suppressed shedding of MICA in human CRC cells without toxicity. This resulted in the reduced production of sMICA. In the clinical examination, patients with CRC who showed long median PFS (3.7 months) had significantly lower sMICA levels than those with shorter median PFS (1.2 months) (p = 0.045).CONCLUSIONS:
MICA is an attractive agent for manipulating the immunological control of CRC and baseline sMICA levels could be a predictive biomarker for the efficacy of regorafenib treatment.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Antígenos de Histocompatibilidade Classe I
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article