[Research advances on thymosin ß4 in promoting wound healing].
Zhonghua Shao Shang Za Zhi
; 38(4): 378-384, 2022 Apr 20.
Article
em Zh
| MEDLINE
| ID: mdl-35462518
ABSTRACT
With the aging of population and the development of social economy, the incidence of chronic wounds is increasing day by day, while the incidence of burns and trauma remains at a high level, making wound repair an increasingly concerned area in clinical practice. Thymosin ß4 is a naturally occurring small molecule protein in vivo, which is widely distributed in a variety of body fluids and cells, especially in platelets. Thymosin ß4 has biological activities of promoting angiogenesis, anti-inflammation, anti-apoptosis, and anti-fibrosis, and has many important functions in wound repair. Thymosin ß4 has been observed to promote the healing of various wounds, such as burns, diabetic ulcers, pressure ulcers. This paper will review the molecular structure, mechanism of wound healing promotion, pharmacokinetics, and clinical application of thymosin ß4, aiming to introduce its potential in wound treatment and the shortcomings of current researches.
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Base de dados:
MEDLINE
Assunto principal:
Timosina
/
Cicatrização
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article