Your browser doesn't support javascript.
loading
Neuroimmune cardiovascular interfaces control atherosclerosis.
Mohanta, Sarajo K; Peng, Li; Li, Yuanfang; Lu, Shu; Sun, Ting; Carnevale, Lorenzo; Perrotta, Marialuisa; Ma, Zhe; Förstera, Benjamin; Stanic, Karen; Zhang, Chuankai; Zhang, Xi; Szczepaniak, Piotr; Bianchini, Mariaelvy; Saeed, Borhan R; Carnevale, Raimondo; Hu, Desheng; Nosalski, Ryszard; Pallante, Fabio; Beer, Michael; Santovito, Donato; Ertürk, Ali; Mettenleiter, Thomas C; Klupp, Barbara G; Megens, Remco T A; Steffens, Sabine; Pelisek, Jaroslav; Eckstein, Hans-Henning; Kleemann, Robert; Habenicht, Livia; Mallat, Ziad; Michel, Jean-Baptiste; Bernhagen, Jürgen; Dichgans, Martin; D'Agostino, Giuseppe; Guzik, Tomasz J; Olofsson, Peder S; Yin, Changjun; Weber, Christian; Lembo, Giuseppe; Carnevale, Daniela; Habenicht, Andreas J R.
Afiliação
  • Mohanta SK; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany. Sarajo.Mohanta@med.uni-muenchen.de.
  • Peng L; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Sarajo.Mohanta@med.uni-muenchen.de.
  • Li Y; Department of Cardiovascular Internal Medicine, Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Lu S; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Sun T; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Carnevale L; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Perrotta M; Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.
  • Ma Z; Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.
  • Förstera B; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Stanic K; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Zhang C; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität Munich (LMU), Munich, Germany.
  • Zhang X; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität Munich (LMU), Munich, Germany.
  • Szczepaniak P; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Bianchini M; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Saeed BR; Department of Internal and Agricultural Medicine, Jagiellonian University Collegium Medicum, Krakow, Poland.
  • Carnevale R; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Hu D; Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
  • Nosalski R; Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.
  • Pallante F; Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Munich, Germany.
  • Beer M; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Santovito D; Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.
  • Ertürk A; Department for Information Technology, University of Jena, Jena University Hospital, Jena, Germany.
  • Mettenleiter TC; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Klupp BG; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
  • Megens RTA; Institute for Genetic and Biomedical Research, Unit of Milan, National Research Council, Milan, Italy.
  • Steffens S; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität Munich (LMU), Munich, Germany.
  • Pelisek J; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
  • Eckstein HH; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
  • Kleemann R; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Habenicht L; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
  • Mallat Z; Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
  • Michel JB; Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
  • Bernhagen J; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
  • Dichgans M; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • D'Agostino G; Department of Vascular Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Guzik TJ; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Olofsson PS; Department of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
  • Yin C; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.
  • Weber C; II. Medizinische Klinik und Poliklinik, Technische Universität München, Klinikum rechts der Isar, Munich, Germany.
  • Lembo G; Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
  • Carnevale D; Laboratory for Vascular Translational Science, INSERM UMRS 1148, University Paris Diderot (P7), GH Bichat-Claude Bernard, Paris, France.
  • Habenicht AJR; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Nature ; 605(7908): 152-159, 2022 05.
Article em En | MEDLINE | ID: mdl-35477759
Atherosclerotic plaques develop in the inner intimal layer of arteries and can cause heart attacks and strokes1. As plaques lack innervation, the effects of neuronal control on atherosclerosis remain unclear. However, the immune system responds to plaques by forming leukocyte infiltrates in the outer connective tissue coat of arteries (the adventitia)2-6. Here, because the peripheral nervous system uses the adventitia as its principal conduit to reach distant targets7-9, we postulated that the peripheral nervous system may directly interact with diseased arteries. Unexpectedly, widespread neuroimmune cardiovascular interfaces (NICIs) arose in mouse and human atherosclerosis-diseased adventitia segments showed expanded axon networks, including growth cones at axon endings near immune cells and media smooth muscle cells. Mouse NICIs established a structural artery-brain circuit (ABC): abdominal adventitia nociceptive afferents10-14 entered the central nervous system through spinal cord T6-T13 dorsal root ganglia and were traced to higher brain regions, including the parabrachial and central amygdala neurons; and sympathetic efferent neurons projected from medullary and hypothalamic neurons to the adventitia through spinal intermediolateral neurons and both coeliac and sympathetic chain ganglia. Moreover, ABC peripheral nervous system components were activated: splenic sympathetic and coeliac vagus nerve activities increased in parallel to disease progression, whereas coeliac ganglionectomy led to the disintegration of adventitial NICIs, reduced disease progression and enhanced plaque stability. Thus, the peripheral nervous system uses NICIs to assemble a structural ABC, and therapeutic intervention in the ABC attenuates atherosclerosis.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Idioma: En Ano de publicação: 2022 Tipo de documento: Article