Ultra-short celiac disease exhibits differential genetic and immunophenotypic features compared to conventional celiac disease.
Gastroenterol Hepatol
; 45(9): 652-659, 2022 Nov.
Article
em En, Es
| MEDLINE
| ID: mdl-35489585
ABSTRACT
BACKGROUND:
Ultra-short coeliac disease (USCD) is a novel celiac disease (CD) subtype limited to the duodenal bulb (D1). HLA haplotypes and flow cytometry have not been assessed yet.AIMS:
To compare genetic, clinical, serologic, histopathologic and inmmunophenotypic parameters between USCD and conventional celiac disease (CCD) patients.METHODS:
Prospective single-center study in children and adult patients undergoing duodenal biopsies on a gluten-containing diet. Biopsies for histology and flow cytometry were taken separately from D1 and distal duodenum. Biopsies in seronegative patients with celiac lymphogram were repeated after 2 years on a gluten-free diet.RESULTS:
Among 505 included patients, 127 were diagnosed with CD, of whom 7 (5.5%) showed USCD. HLADQ2 was significantly less common in USCD compared to CCD (71% vs. 95%, p 0.003). Likewise, USCD patients showed more frequent non-significant seronegativity (28% vs. 8%, p 0.07) and significantly lower titrations (7-15IU/ml) of tissue transglutaminase antibodies (tTG-IgA) (60% vs. 13%, p<0.001). Biopsies from D1 revealed significant less NK cells down-expression in USCD patients (1.4 vs. 5, p 0.04).CONCLUSIONS:
Up to 5.5% of CD patients showed USCD. A lower frequency of HLADQ2, along with less serum tTG-IgA titration and duodenal NK cell suppression, were differential features of USCD.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Celíaca
Idioma:
En
/
Es
Ano de publicação:
2022
Tipo de documento:
Article