Lipase-Catalyzed Kinetic Resolution of C1-Symmetric Heterocyclic Biaryls.
Chem Pharm Bull (Tokyo)
; 70(5): 391-399, 2022.
Article
em En
| MEDLINE
| ID: mdl-35491196
ABSTRACT
The highly enantioselective lipase-catalyzed kinetic resolution (KR) of racemic C1-symmetric biaryl compounds including heterocyclic moieties, such as carbazole and dibenzofuran, has been achieved for the first time. This enzymatic esterification was accelerated by the addition of disodium carbonate while maintaining its high enantioselectivities, and was particularly effective for biaryls having N-substituted carbazole moieties. Furthermore, mesoporous silica-supported oxovanadium-catalyzed cross-dehydrogenative coupling of 3-hydroxycarbazole and 2-naphthol was followed by the lipase-catalyzed KR in one-pot to synthesize the optically active heterocyclic biaryl compounds with high optical purity.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carbazóis
/
Lipase
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article