The Role of TDP-43 in Neurodegenerative Disease.
Mol Neurobiol
; 59(7): 4223-4241, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35499795
ABSTRACT
In recent years, more and more neurodegenerative diseases, such as ALS, FTLD and AD, have been found to share a common pathological feature, which is the depletion of TDP-43 in the nucleus and the accumulation of TDP-43 in the cytoplasm through hyperphosphorylation, ubiquitination and cleavage. Therefore, this kind of neurodegenerative disease is also called TDP-43 proteinopathy. This suggests that TDP-43 plays a role in the pathogenesis of disease. Current studies show that the pathophysiological mechanism of TDP-43 in neurodegeneration is very complex. In this review, we describe the structure of TDP-43, its main physiological functions, the possible pathogenesis and how TDP-43 provides a new pathway to treat neurodegenerative diseases.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Neurodegenerativas
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Proteinopatias TDP-43
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Esclerose Lateral Amiotrófica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article