A low dose adenovirus vectored vaccine expressing Schistosoma mansoni Cathepsin B protects from intestinal schistosomiasis in mice.

Perera, Dilhan J; Hassan, Adam S; Liu, Sunny S; Elahi, Seyyed Mehdy; Gadoury, Christine; Weeratna, Risini D; Gilbert, Rénald; Ndao, Momar

Perera, Dilhan J; Hassan, Adam S; Liu, Sunny S; Elahi, Seyyed Mehdy; Gadoury, Christine; Weeratna, Risini D; Gilbert, Rénald; Ndao, Momar.

Afiliação

Perera DJ; Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec, Canada; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Room: EM3.3244, 1001 Decarie Blvd, Montréal, Québec H4A 3J1, Canada.
Hassan AS; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Room: EM3.3244, 1001 Decarie Blvd, Montréal, Québec H4A 3J1, Canada; Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.
Liu SS; Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada.
Elahi SM; National Research Council Canada, Montréal, Québec, Canada.
Gadoury C; National Research Council Canada, Montréal, Québec, Canada.
Weeratna RD; National Research Council Canada, Ottawa, Ontario, Canada.
Gilbert R; National Research Council Canada, Montréal, Québec, Canada.
Ndao M; Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec, Canada; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Room: EM3.3244, 1001 Decarie Blvd, Montréal, Québec H4A 3J1, Canada; Departmen

EBioMedicine ; 80: 104036, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35500538

Assuntos

Vacinas contra Adenovirus; Esquistossomose mansoni; Esquistossomose; Vacinas; Adenoviridae/genética; Animais; Anticorpos Anti-Helmínticos; Antígenos de Helmintos; Canadá; Catepsina B/genética; Feminino; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Schistosoma mansoni/genética; Esquistossomose mansoni/prevenção & controle

Palavras-chave

Heterologous; Parasite; Prime and boost; Schistosoma mansoni; Schistosomiasis; Vaccine; Viral vector

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquistossomose / Esquistossomose mansoni / Vacinas / Vacinas contra Adenovirus Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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