Nanozyme-natural enzymes cascade catalyze cholesterol consumption and reverse cancer multidrug resistance.
J Nanobiotechnology
; 20(1): 209, 2022 May 02.
Article
em En
| MEDLINE
| ID: mdl-35501796
ABSTRACT
Multidrug resistance is still a major obstacle to cancer treatment. The most studies are to inhibit the activity of the drug transporter P-glycoprotein (P-gp), but the effect is not ideal. Herein, a nanosystem was built based on cascade catalytic consumption of cholesterol. Cholesterol oxidase (natural enzyme, COD) was immobilized on the carrier (NH2-MIL-88B, MOF) through amide reaction, COD catalyzed the consumption of cholesterol, the reaction product H2O2 was further produced by the MOF with its peroxidase-like activity to produce hydroxyl radicals (â¢OH) with killing effect. Due to the high expression of CD44 receptor on the surface of tumor cells, we encapsulated chondroitin sulfate gel shell (CS-shell) with CD44 targeting and apoptosis promoting effect on the surface of DOX@MOF-COD nanoparticles, which can accurately and efficiently deliver the drugs to the tumor site and improve the effect of reversing drug resistance. Taking drug-resistant cell membrane as "breakthrough", this paper will provide a new idea for reversing multidrug resistance of tumor.
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MEDLINE
Assunto principal:
Peróxido de Hidrogênio
/
Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article