Covid19 vaccination-associated portal vein thrombosis-An interdisciplinary clinical challenge.
Clin Res Hepatol Gastroenterol
; 46(8): 101932, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35504460
ABSTRACT
Despite one of the largest vaccination campaigns in human history, the COVID-19 pandemic has not been yet defeated. More than 10 billion doses of COVID-19 vaccine have been administered worldwide. AstraZeneca's Vaxzevria (ChAdOx1 nCoV-19 / AZD1222) was approved as the first viral vector-based vaccine in the EU on 29 January 2021. Thromboembolic events are a rare complication of vaccination with ChAdOx1 nCoV-19 in the context of, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT), with an incidence of 1.5-3 in 100,000 vaccinations. VITT is clinically as well as pathophysiologically comparable to heparin-induced thrombocytopenia. Illustrated by a fulminant patient case, a multidisciplinary step-by-step guideline was developed for the recognition, diagnosis, and management of patients with severe acute portosplanchic venous thrombosis with mesenteric ischemia due to vaccine-induced immunogenic thrombotic thrombocytopenia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
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Trombose
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Trombose Venosa
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COVID-19
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Hepatopatias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article