Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species.

Fader, Kelly A; Pardo, Ingrid D; Kovi, Ramesh C; Somps, Christopher J; Wang, Helen Hong; Vaidya, Vishal S; Ramaiah, Shashi K; Sirivelu, Madhu P.

Afiliação

Fader KA; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Groton, CT 06340, USA.
Pardo ID; Biogen, Cambridge, MA 02142, USA.
Kovi RC; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Pfizer Inc., 300 Technology Square, Cambridge, MA 02139, USA.
Somps CJ; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Groton, CT 06340, USA.
Wang HH; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Pfizer Inc., 300 Technology Square, Cambridge, MA 02139, USA.
Vaidya VS; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Pfizer Inc., 300 Technology Square, Cambridge, MA 02139, USA.
Ramaiah SK; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Pfizer Inc., 300 Technology Square, Cambridge, MA 02139, USA.
Sirivelu MP; Pfizer Worldwide Research, Development and Medical, Drug Safety Research and Development, Pfizer Inc., 300 Technology Square, Cambridge, MA 02139, USA.

Mol Ther Methods Clin Dev ; 25: 264-277, 2022 Jun 09.

Article em En | MEDLINE | ID: mdl-35505662