An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.
Cell Rep
; 39(5): 110775, 2022 05 03.
Article
em En
| MEDLINE
| ID: mdl-35508124
ABSTRACT
Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a ventral tegmental area DA projection to the amygdala (VTADAâamygdala) for cocaine-induced anxiety but not cocaine reward or sensitization. Our rabies virus-mediated circuit mapping approach reveals a persistent elevation in spontaneous and task-related activity of inhibitory GABAergic cells from the bed nucleus of the stria terminalis (BNST) and downstream VTADAâamygdala cells that can be detected even after a single cocaine exposure. Activity in BNSTGABAâmidbrain cells is related to cocaine-induced anxiety but not reward or sensitization, and silencing this projection prevents development of anxiety during protracted withdrawal after cocaine administration. Finally, we observe that VTADAâamygdala cells are strongly activated after a challenge exposure to cocaine and that activity in these cells is necessary and sufficient for reinstatement of cocaine place preference.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cocaína
/
Transtornos Relacionados ao Uso de Cocaína
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article