A UK consensus algorithm for early treatment modification in newly diagnosed systemic light-chain amyloidosis.
Br J Haematol
; 198(2): 328-332, 2022 07.
Article
em En
| MEDLINE
| ID: mdl-35509237
ABSTRACT
Depth of response is the critical determinant of prognosis in amyloid light-chain (AL) amyloidosis. Here, we aim to identify patients who are unlikely to improve response based on analysis of baseline characteristics and 1-month response. In a multivariate model, difference in involved amyloidogenic and uninvolved serum free light chains (dFLC) at diagnosis (dFLC >400 mg/l, odds ratio [OR] 4.051, p < 0.005) and no response at 1 month (OR 4.787, p < 0.005) were significant predictors of no improvement in response. Only 5% of patients with a dFLC of >400 mg/l and no response at 1 month improved their response (p < 0.005). We suggest that these patients should switch treatment early, subject to their functional status.
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Base de dados:
MEDLINE
Assunto principal:
Amiloidose de Cadeia Leve de Imunoglobulina
/
Amiloidose
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article