Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles.

Van den Broek, Bram; Wuyts, Charlotte; Sisto, Angela; Pintelon, Isabel; Timmermans, Jean-Pierre; Somers, Veerle; Timmerman, Vincent; Hellings, Niels; Irobi, Joy

Van den Broek, Bram; Wuyts, Charlotte; Sisto, Angela; Pintelon, Isabel; Timmermans, Jean-Pierre; Somers, Veerle; Timmerman, Vincent; Hellings, Niels; Irobi, Joy.

Afiliação

Van den Broek B; Department of Immunology and Infections, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Wuyts C; Department of Immunology and Infections, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Sisto A; Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge and University of Antwerp, Antwerp, Belgium.
Pintelon I; Laboratory of Cell Biology & Histology, Antwerp Centre for Advanced Microscopy (ACAM), University of Antwerp, Antwerp, Belgium.
Timmermans JP; Laboratory of Cell Biology & Histology, Antwerp Centre for Advanced Microscopy (ACAM), University of Antwerp, Antwerp, Belgium.
Somers V; Department of Immunology and Infections, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Timmerman V; Peripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge and University of Antwerp, Antwerp, Belgium.
Hellings N; Department of Immunology and Infections, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Irobi J; Department of Immunology and Infections, Biomedical Research Institute, Hasselt University, Hasselt, Belgium. joy.irobi@uhasselt.be.

Cell Commun Signal ; 20(1): 58, 2022 05 05.

Article em En | MEDLINE | ID: mdl-35513867

Assuntos

Vesículas Extracelulares; Proteínas de Choque Térmico; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteínas Reguladoras de Apoptose/metabolismo; Autofagia; Vesículas Extracelulares/metabolismo; Proteínas de Choque Térmico/metabolismo; Humanos; Inflamação/metabolismo; Chaperonas Moleculares/metabolismo; Oligodendroglia/metabolismo; Oligodendroglia/patologia; Estresse Oxidativo

Palavras-chave

CNS; Cellular inflammation; Engineered nanocarriers; Extracellular vesicles; Microglia; Molecular chaperones; Oligodendroglia; Small heat shock protein 8

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Proteínas de Choque Térmico Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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