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Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia.
Umehara, Yui; Kageyama, Toki; Son, Aoi; Kimura, Yu; Kondo, Teruyuki; Tanabe, Kazuhito.
Afiliação
  • Umehara Y; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku Kyoto 615-8510 Japan teruyuki@scl.kyoto-u.ac.jp +81-75-383-2504 +81-75-383-7055.
  • Kageyama T; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku Kyoto 615-8510 Japan teruyuki@scl.kyoto-u.ac.jp +81-75-383-2504 +81-75-383-7055.
  • Son A; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku Kyoto 615-8510 Japan teruyuki@scl.kyoto-u.ac.jp +81-75-383-2504 +81-75-383-7055.
  • Kimura Y; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku Kyoto 615-8510 Japan teruyuki@scl.kyoto-u.ac.jp +81-75-383-2504 +81-75-383-7055.
  • Kondo T; Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku Kyoto 615-8510 Japan teruyuki@scl.kyoto-u.ac.jp +81-75-383-2504 +81-75-383-7055.
  • Tanabe K; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University 5-10-1 Fuchinobe, Chuo-ku Sagamihara 252-5258 Japan tanabe.kazuhito@chem.aoyama.ac.jp +81-42-759-6493 +81-42-759-6229.
RSC Adv ; 9(29): 16863-16868, 2019 May 24.
Article em En | MEDLINE | ID: mdl-35516361
ABSTRACT
Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signal in hypoxic tumor cells and tissues.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article