The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis.

Zhang, Ling-Xian; Gao, Jian; Long, Xiang; Zhang, Peng-Fei; Yang, Xin; Zhu, Shu-Qiang; Pei, Xu; Qiu, Bai-Quan; Chen, Shi-Wei; Lu, Feng; Lin, Kun; Xu, Jian Jun; Wu, Yong-Bing

Zhang, Ling-Xian; Gao, Jian; Long, Xiang; Zhang, Peng-Fei; Yang, Xin; Zhu, Shu-Qiang; Pei, Xu; Qiu, Bai-Quan; Chen, Shi-Wei; Lu, Feng; Lin, Kun; Xu, Jian Jun; Wu, Yong-Bing.

Afiliação

Zhang LX; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Gao J; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.
Long X; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Zhang PF; Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Yang X; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Zhu SQ; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Pei X; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Qiu BQ; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Chen SW; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Lu F; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Lin K; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Xu JJ; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China.
Wu YB; Department of Cardiothoracic Surgery, the Second Affiliated Hospital of Nanchang University, 1 Ming de Road, Nanchang, 330000, Jiangxi, People's Republic of China. wuyongbing789@163.com.

Mol Cancer ; 21(1): 110, 2022 05 07.

Article em En | MEDLINE | ID: mdl-35525959

Assuntos

Adenocarcinoma de Pulmão; Carcinoma de Células Escamosas; Neoplasias Pulmonares; MicroRNAs; Proteína-Arginina N-Metiltransferases; Adenocarcinoma de Pulmão/tratamento farmacológico; Adenocarcinoma de Pulmão/genética; Animais; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/genética; Proliferação de Células; Regulação Neoplásica da Expressão Gênica; Proteína HMGB2/genética; Humanos; Terapia de Imunossupressão; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Camundongos; MicroRNAs/genética; Proteína-Arginina N-Metiltransferases/genética; RNA Circular/genética; Microambiente Tumoral

Palavras-chave

Anti-PD-1 treatment; CARM1; NSCLC; TME; circHMGB2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Carcinoma de Células Escamosas / MicroRNAs / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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