TBK1 participates in glutaminolysis by mediating the phosphorylation of RIPK3 to promote endotoxin tolerance.

Pan, Lehan; Yang, Lian; Yi, Zhujun; Zhang, Wenfeng; Gong, Jianping

Pan, Lehan; Yang, Lian; Yi, Zhujun; Zhang, Wenfeng; Gong, Jianping.

Afiliação

Pan L; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yang L; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yi Z; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Hepatobiliary Surgery, Chongqing University Three Gorges Hospital, Chongqing, China.
Zhang W; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: zhangwenfeng@cqmu.edu.cn.
Gong J; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: 300381@hospital.cqmu.edu.cn.

Mol Immunol ; 147: 101-114, 2022 07.

Article em En | MEDLINE | ID: mdl-35533409

Assuntos

Glutamina; Proteínas Serina-Treonina Quinases; Tolerância à Endotoxina; Glutamina/metabolismo; Humanos; Quinase I-kappa B/metabolismo; Inflamação; Lipopolissacarídeos/metabolismo; Lipopolissacarídeos/farmacologia; Fosforilação; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo

Palavras-chave

Endotoxin tolerance; GLUD1; RIPK3; Sepsis; TBK1; α-KG

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Glutamina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Glutamina Idioma: En Ano de publicação: 2022 Tipo de documento: Article