Enhanced aqueous dissolution of hydrophobic apixaban via direct incorporation of hydrophilic nanographene oxide.

Islam, Mohammad Saiful; Renner, Faradae; Foster, Kimberly; Oderinde, Martins S; Stefanski, Kevin; Mitra, Somenath

Islam, Mohammad Saiful; Renner, Faradae; Foster, Kimberly; Oderinde, Martins S; Stefanski, Kevin; Mitra, Somenath.

Afiliação

Islam MS; Department of Chemistry and Environmental science, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Renner F; Department of Chemistry and Environmental science, New Jersey Institute of Technology, Newark, NJ, 07102, USA; Bristol Myers Squibb Research and Early Development, Princeton, NJ 08543, USA.
Foster K; Bristol Myers Squibb Research and Early Development, Princeton, NJ 08543, USA.
Oderinde MS; Bristol Myers Squibb Research and Early Development, Princeton, NJ 08543, USA.
Stefanski K; Bristol Myers Squibb Research and Early Development, Princeton, NJ 08543, USA.
Mitra S; Department of Chemistry and Environmental science, New Jersey Institute of Technology, Newark, NJ, 07102, USA. Electronic address: somenath.mitra@njit.edu.

Colloids Surf B Biointerfaces ; 216: 112512, 2022 Aug.

Article em En | MEDLINE | ID: mdl-35533561

Assuntos

Grafite; Pirazóis; Piridonas; Grafite/química; Interações Hidrofóbicas e Hidrofílicas; Nanopartículas; Óxidos; Pirazóis/química; Piridonas/química; Solubilidade; Água/química

Palavras-chave

Bioavailability; Direct incorporation; Enhanced dissolution; Graphene oxide; Hydrophobic apixaban; Paddle method

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Piridonas / Grafite Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Piridonas / Grafite Idioma: En Ano de publicação: 2022 Tipo de documento: Article