Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging.

In this study, we report the preparation and characterization of the PVA-DTPA-Gd conjugate as a potential MRI contrast agent (CA). The r 1 value and the r 2/r 1 ratio were about 5.6 mM-1 s-1 and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.