Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Lu, Hua Rong; Kreir, Mohamed; Karel, Van Ammel; Tekle, Fetene; Geyskens, Danny; Teisman, Ard; Gallacher, David J

Lu, Hua Rong; Kreir, Mohamed; Karel, Van Ammel; Tekle, Fetene; Geyskens, Danny; Teisman, Ard; Gallacher, David J.

Afiliação

Lu HR; Global Safety Pharmacology, Predictive, Investigative and Translational Toxicology, Nonclinical Safety, Beerse, Belgium.
Kreir M; Global Safety Pharmacology, Predictive, Investigative and Translational Toxicology, Nonclinical Safety, Beerse, Belgium.
Karel VA; Global Safety Pharmacology, Predictive, Investigative and Translational Toxicology, Nonclinical Safety, Beerse, Belgium.
Tekle F; Discovery and Nonclinical Safety Statistics, Statistics and Decision Sciences, Quantitative Sciences, Janssen R&D, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
Geyskens D; Global Safety Pharmacology, Predictive, Investigative and Translational Toxicology, Nonclinical Safety, Beerse, Belgium.
Teisman A; Global Safety Pharmacology, Predictive, Investigative and Translational Toxicology, Nonclinical Safety, Beerse, Belgium.
Gallacher DJ; Global Safety Pharmacology, Predictive, Investigative and Translational Toxicology, Nonclinical Safety, Beerse, Belgium.

Front Physiol ; 13: 838435, 2022.

Article em En | MEDLINE | ID: mdl-35547580