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A voltage trade study for the design of capillary electrophoresis instruments for spaceflight.
Ferreira Santos, Mauro S; Kurfman, Emily; Zamuruyev, Konstantin; Noell, Aaron C; Mora, Maria F; Willis, Peter A.
Afiliação
  • Ferreira Santos MS; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.
  • Kurfman E; Department of Chemistry, University of Kansas, Lawrence, Kansas, USA.
  • Zamuruyev K; Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, Kansas, USA.
  • Noell AC; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.
  • Mora MF; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.
  • Willis PA; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.
Electrophoresis ; 44(1-2): 10-14, 2023 01.
Article em En | MEDLINE | ID: mdl-35569140
Capillary electrophoresis (CE) systems have undergone extensive development for spaceflight applications. A flight-compatible high voltage power supply and the necessary voltage isolation for other energized components can be large contributors to both the volume and mass of a CE system, especially if typical high voltage levels of 25-30 kV are used. Here, we took advantage of our custom CE hardware to perform a trade study for simultaneous optimization of capillary length, high voltage level, and separation time, without sacrificing method performance. A capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4 D) method recently developed by our group to target inorganic cations and amino acids relevant to astrobiology was used as a test case. The results indicate that a 50 cm long capillary with 15 kV applied voltage (half of that used in the original method) can be used to achieve measurement goals while minimizing instrument size.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eletroforese Capilar Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eletroforese Capilar Idioma: En Ano de publicação: 2023 Tipo de documento: Article