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Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease.
Fang, Jiansong; Zhang, Pengyue; Zhou, Yadi; Chiang, Chien-Wei; Tan, Juan; Hou, Yuan; Stauffer, Shaun; Li, Lang; Pieper, Andrew A; Cummings, Jeffrey; Cheng, Feixiong.
Afiliação
  • Fang J; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Zhang P; Department of Biostatistics, School of Medicine, Indiana University.
  • Zhou Y; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Chiang CW; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
  • Tan J; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Hou Y; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Stauffer S; Center for Therapeutics Discovery, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Li L; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
  • Pieper AA; Harrington Discovery Institute, University Hospital Case Medical Center; Department of Psychiatry, Case Western Reserve University, Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland VAMC, Cleveland, OH 44106, USA.
  • Cummings J; Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
  • Cheng F; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Nat Aging ; 1(12): 1175-1188, 2021 12.
Article em En | MEDLINE | ID: mdl-35572351
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2021 Tipo de documento: Article