Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: where we stand.

Shyam, Mousumi; Shilkar, Deepak; Rakshit, Gourav; Jayaprakash, Venkatesan

Shyam, Mousumi; Shilkar, Deepak; Rakshit, Gourav; Jayaprakash, Venkatesan.

Afiliação

Shyam M; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Shilkar D; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Rakshit G; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Jayaprakash V; Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, India.

Expert Opin Drug Discov ; 17(7): 699-715, 2022 07.

Article em En | MEDLINE | ID: mdl-35575503

Assuntos

Mycobacterium tuberculosis; Antituberculosos/farmacologia; Proteínas de Bactérias; Descoberta de Drogas; Humanos; Ferro/metabolismo; Oxazóis; Sideróforos/metabolismo; Sideróforos/farmacologia

Palavras-chave

Drug resistance; HupB; IdeR; MbtA; MbtI; conditionally essential targets; efflux-pump; essential targets; iron-starvation; iron-toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mycobacterium tuberculosis Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mycobacterium tuberculosis Idioma: En Ano de publicação: 2022 Tipo de documento: Article