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The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants.
Cao, Liu; Li, Yingjun; Yang, Sidi; Li, Guanguan; Zhou, Qifan; Sun, Jing; Xu, Tiefeng; Yang, Yang; Liao, Ruyan; Shi, Yongxia; Yang, Yujian; Zhu, Tiaozhen; Huang, Siyao; Ji, Yanxi; Cong, Feng; Luo, Yinzhu; Zhu, Yujun; Luan, Hemi; Zhang, Huan; Chen, Jingdiao; Liu, Xue; Luo, Renru; Liu, Lihong; Wang, Ping; Yu, Yang; Xing, Fan; Ke, Bixia; Zheng, Huanying; Deng, Xiaoling; Zhang, Wenyong; Lin, Chuwen; Shi, Mang; Li, Chun-Mei; Zhang, Yu; Zhang, Lu; Dai, Jun; Lu, Hongzhou; Zhao, Jincun; Zhang, Xumu; Guo, Deyin.
Afiliação
  • Cao L; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Li Y; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Yang S; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Li G; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Zhou Q; Medi-X Pingshan, Southern University of Science and Technology, Shenzhen 518118, Guangdong, China.
  • Sun J; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Xu T; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, Guangdong, China.
  • Yang Y; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Liao R; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, Guangdong, China.
  • Shi Y; Guangzhou Customs District Technology Center, Guangzhou 510623, Guangdong, China.
  • Yang Y; Guangzhou Customs District Technology Center, Guangzhou 510623, Guangdong, China.
  • Zhu T; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Huang S; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Ji Y; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Cong F; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Luo Y; Guangdong Province Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, Guangdong, China.
  • Zhu Y; Guangdong Province Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, Guangdong, China.
  • Luan H; Guangdong Province Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, Guangdong, China.
  • Zhang H; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Chen J; Center for Disease Control and Prevention of Guangdong Province, Guangzhou 511430, Guangdong, China.
  • Liu X; Center for Disease Control and Prevention of Guangdong Province, Guangzhou 511430, Guangdong, China.
  • Luo R; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Liu L; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Wang P; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Yu Y; Medi-X Pingshan, Southern University of Science and Technology, Shenzhen 518118, Guangdong, China.
  • Xing F; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Department of Chemistry, College of Science, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Ke B; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Zheng H; Center for Disease Control and Prevention of Guangdong Province, Guangzhou 511430, Guangdong, China.
  • Deng X; Center for Disease Control and Prevention of Guangdong Province, Guangzhou 511430, Guangdong, China.
  • Zhang W; Center for Disease Control and Prevention of Guangdong Province, Guangzhou 511430, Guangdong, China.
  • Lin C; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.
  • Shi M; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Li CM; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Zhang Y; Centre for Infection and Immunity Studies (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China.
  • Zhang L; Guangdong Province Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510663, Guangdong, China.
  • Dai J; Guangzhou Customs District Technology Center, Guangzhou 510623, Guangdong, China.
  • Lu H; Guangzhou Customs District Technology Center, Guangzhou 510623, Guangdong, China.
  • Zhao J; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, Guangdong, China.
  • Zhang X; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, Guangdong, China.
  • Guo D; Guangzhou Laboratory, Bio Island, Guangzhou 510320, Guangdong, China.
Sci Transl Med ; 14(661): eabm7621, 2022 09 07.
Article em En | MEDLINE | ID: mdl-35579533
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Tratamento Farmacológico da COVID-19 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Tratamento Farmacológico da COVID-19 Idioma: En Ano de publicação: 2022 Tipo de documento: Article