A Degenerate Metal-Templated Catalytic System with Redundant Functional Groups for the Asymmetric Aldol Reaction.
J Org Chem
; 87(11): 7509-7513, 2022 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-35583468
ABSTRACT
A degenerate zinc-templated catalytic system containing two bipyridine ligands with redundant functional groups for either enamine or hydrogen bond formation was applied to the asymmetric aldol reaction. This concept led to both a higher probability of reaction and rate acceleration. Thus, the catalyst loading could be decreased to a remarkable 2 mol % in what we think is a general approach.
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MEDLINE
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En
Ano de publicação:
2022
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Article