Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and &#945;-synuclein accumulation in the colon of two Parkinson's disease mouse models.

Su, Yunfang; Liu, Ningning; Zhang, Zijuan; Li, Hao; Ma, Jinlian; Yuan, Ye; Shi, Ming; Liu, Jihong; Zhao, Zhenrong; Zhang, Zhenqiang; Holscher, Christian

Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models.

Su, Yunfang; Liu, Ningning; Zhang, Zijuan; Li, Hao; Ma, Jinlian; Yuan, Ye; Shi, Ming; Liu, Jihong; Zhao, Zhenrong; Zhang, Zhenqiang; Holscher, Christian.

Afiliação

Su Y; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Liu N; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Zhang Z; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Li H; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Ma J; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Yuan Y; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Shi M; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Liu J; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Zhao Z; School of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China.
Zhang Z; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China. Electronic address: 13333719963@126.com.
Holscher C; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, Henan province, China; Department of Neurology, The Second Affiliated Hospital of Shanxi Medical University, No. 382 Wuyi Road, Taiyuan, 030001, Shanxi province, China. Electronic address: c.holscher@hactcm

Eur J Pharmacol ; 926: 175029, 2022 Jul 05.

Article em En | MEDLINE | ID: mdl-35584709

Assuntos

Doenças Neurodegenerativas; Doença de Parkinson; 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina; Animais; Colecistocinina; Colo/patologia; Modelos Animais de Doenças; Neurônios Dopaminérgicos/patologia; Peptídeo 1 Semelhante ao Glucagon/farmacologia; Humanos; Inflamação/tratamento farmacológico; Liraglutida; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Doença de Parkinson/tratamento farmacológico; Doença de Parkinson/patologia; Junções Íntimas/patologia; alfa-Sinucleína

Palavras-chave

A53T α-synuclein; CCK; GLP-1; Gut; MPTP; Parkinson's disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Doenças Neurodegenerativas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Doenças Neurodegenerativas Idioma: En Ano de publicação: 2022 Tipo de documento: Article