Emerging tissue engineering strategies for the corneal regeneration.
J Tissue Eng Regen Med
; 16(8): 683-706, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35585479
ABSTRACT
Cornea as the outermost layer of the eye is at risk of various genetic and environmental diseases that can damage the cornea and impair vision. Corneal transplantation is among the most applicable surgical procedures for repairing the defected tissue. However, the scarcity of healthy tissue donations as well as transplantation failure has remained as the biggest challenges in confront of corneal grafting. Therefore, alternative approaches based on stem-cell transplantation and classic regenerative medicine have been developed for corneal regeneration. In this review, the application and limitation of the recently-used advanced approaches for regeneration of cornea are discussed. Additionally, other emerging powerful techniques such as 5D printing as a new branch of scaffold-based technologies for construction of tissues other than the cornea are highlighted and suggested as alternatives for corneal reconstruction. The introduced novel techniques may have great potential for clinical applications in corneal repair including disease modeling, 3D pattern scheming, and personalized medicine.
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Base de dados:
MEDLINE
Assunto principal:
Engenharia Tecidual
/
Bioimpressão
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article